Ablazione.org – Terapia delle aritmie

A cura del Dr. Igino Contrafatto M.D. – Cardiac Electrophysiology – Salus Hospital – Reggio Emilia

Underdosage of Betablockers in HF

Betablockers Underdosage in Heart Failure Patients.
Review of 1,798 patients from RAFT Study, where cardiac resynchronization therapy was used on top of optimal medical therapy, showed that patients treated with higher dosage of betablockers had one-third reduction of all-cause mortality or heart failure hospitalization, compared with patients receiving less than half the recommended dosage.

Two-thirds

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of the patients on carvedilol

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received at least half of the recommended target dosage of 50 mg/day. In contrast, about a third of patients being treated with either bisoprolol or metoprolol received a dosage that was at least half the target dosage (10 mg/day for bisoprolol, 200 mg/day for metoprolol).

Data source: A post hoc subgroup analysis of results from RAFT, with 1,798 patients with heart failure at 34 worldwide sites. RAFT Study N. Engl. J. Med. 2010;363:2385-95